Voltage-gated potassium channel antibody encephalopathy, a rare cause of
limbic encephalopathy, typically presents with memory impairment and
seizures. Psychiatric symptoms have not been emphasised in the literature.
Here we describe a 58-year-old man who presented with panic attacks and
psychogenic non-epileptic seizures and, later on, developed delusions and
hallucinations and then confusion. He was found to have antibodies to
voltage-gated potassium channels. Treatment with immuno-modulatory therapy
resulted in almost complete recovery.